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CXCL5 Protein, Human, Recombinant

CAT: 0882-PH50785E0-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PH50785E0-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CXCL5 is a small cytokine belonging to the CXC chemokine family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL5 is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. It also can be detected in eosinophils, and can be inhibited with the type II interferon. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis. It stimulates the chemotaxis of neutrophils possesses angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.
Overview
A DNA sequence encoding the human CXCL5 (P42830) (Arg45-Asn114) was expressed, with a N-terminal Met.
Synonyms
ENA-78 Protein, Human; SCYB5 Protein, Human
Gene Name
Chemokine (C-X-C motif) ligand 5
UniProt
P42830
Expression System
E. coli
Tag
No tag
Endotoxin
Please contact us for more information.
Purity
> 95 % as determined by SDS-PAGE.
Activity
At Leading Biology, the biological activity of a recombinant protein is routinely measured using a bioassay, e.g. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. When a recombinant protein is an enzyme, specific activity is derived from an enzymatic assay. Each enzyme is tested for potency by cleavage of a substrate. We are in the process of updating the biological activity data. If you have any questions regarding this update, please feel free to contact our technical support team.
Form
Lyophilized
Buffer
Lyophilized from sterile 80% acetonitrile, 0.1% TFA, 20% H2O Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
Cytokine Proteins, Growth Factor proteins, Biological Target proteins, Biomarker Proteins
Molecular Weight
The recombinant human CXCL5 consists of 71 amino acids and predicts a molecular mass of 7.8 KDa. It migrates as an approximately 8 KDa band in SDS-PAGE under reducing conditions.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CXCL5
Species
Human
Uniprot URL
https://www.uniprot.org/uniprot/P42830
AA Sequence
Arg45-Asn114

UniProtKB · P42830

C-X-C motif chemokine 5

CXCL5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P42830
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CXCL5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q96QE1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

Cytokine

PTM

Disulfide bond

Cellular component

Secreted

Domain

Signal

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