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CD155/PVR Protein, Human, Recombinant

CAT: 0882-PH50212M0Size: 200 µgDry Ice: NoHazardous: No
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CAT#:0882-PH50212M0Size:200 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.
Overview
A DNA sequence encoding the human PVR (AAA36462.1) (Met1-Asn343) was expressed.
Synonyms
CD155 Protein, Human; HVED Protein, Human; Necl-5 Protein, Human; NECL5 Protein, Human; PVS Protein, Human; TAGE4 Protein, Human
Gene Name
Poliovirus receptor
Expression System
HEK293 Cells
Tag
No tag
Field of Research
Cancer Drug Targets
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Purity
> 90 % as determined by SDS-PAGE.
Activity
Measured by its ability to bind human TIGI-hFc in a functional ELISA.
Form
Lyophilized
Buffer
Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Function
CD Molecule proteins, Cancer proteins, Immunotherapy proteins, Immune Checkpoint Proteins, Biological Target proteins
Molecular Weight
The recombinant human PVR consists of 323 amino acids and predicts a molecular mass of 35.1 kDa.
Storage Conditions
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PVR
Species
Human
Protein ID
AAA36462.1
AA Sequence
Met1-Asn343
Protein ID Link
https://www.ncbi.nlm.nih.gov/protein/AAA36462.1

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