PSMC6 Antibody - C-terminal region: HRP (ARP59359_P050-HRP)

• Gene Name:

  Proteasome (prosome, macropain) 26S subunit, ATPase, 6

• Gene Aliases:

  P42, RPT5, SUG2

• Gene ID:

  5706

• Swiss Prot:

  P62333

• Accession Number:

  NP_002797

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human PSMC6

• Target:

  The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.

• Partner Proteins:

  SDCBP; CCDC146; CYB5R2; HUWE1; UBC; PSMD9; PSMC6; PSMC3; SUMO2; STAU1; PSMD14; MDM2; ABCF1; UBR4; ADRM1; TXNL1; AIMP1; AIMP2; RPS21; RPS15A; RPS12; RPS8; QARS; PSMD12; PSMD11; PSMD8; PSMD4; UCHL5; DYNC1LI1; PSMD3; PSMD2; PSMD1; PSMC5; PSMC2; PSMC1; PARK2

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Sample Type:

  PSMC6 is supported by BioGPS gene expression data to be expressed in 721_B, MCF7

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 86%; Zebrafish: 100%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  44kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  389

• NCBI Gene Symbol:

  PSMC6

• Protein Name:

  26S protease regulatory subunit 10B

• Nucleotide Accession Number:

  NM_002806