RUNX1T1 Antibody - middle region: FITC (ARP58127_P050-FITC)

• Gene Name:

  Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

• Gene Aliases:

  CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1, AML1-MTG8

• Gene ID:

  862

• Swiss Prot:

  B2R6I9

• Accession Number:

  NP_004340

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the middle region of human RUNX1T1

• Target:

  RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.

• Partner Proteins:

  EPS8; NECAB2; ABI3; GSE1; MID2; SPRY2; HOMER3; LPXN; ZMYM4; STX11; MEOX2; CCDC36; TRIM42; SPERT; CREB3L1; LZTS2; EFHC2; CPSF7; C19orf57; PRDM14; CBFA2T2; NCOR1; UBQLN4; ATN1; BCL6; ETS1; RUNX1; DNMT1; SPEN; RBPJ; UBE2E2; UBC; TRIM33; HDAC1; NCOR2; SIN3A

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 86%; Zebrafish: 93%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  64kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  577

• NCBI Gene Symbol:

  RUNX1T1

• Protein Name:

  CDNA, FLJ92968, highly similar to Homo sapiens runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 1, mRNA EMBL BAG35486.1

• Nucleotide Accession Number:

  NM_004349