TXNIP Antibody - C-terminal region : Biotin (ARP52193_P050-Biotin)

• Gene Name:

  Thioredoxin interacting protein

• Gene Aliases:

  THIF, VDUP1, ARRDC6, HHCPA78, EST01027

• Gene ID:

  10628

• Swiss Prot:

  Q9H3M7

• Accession Number:

  NP_006463

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human TXNIP

• Target:

  TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells.

• Partner Proteins:

  UBC; DDIT4; ECD; TXN; TP53; SMURF2; UL49; ITCH; ELAVL1; FHL1; ZBTB32; ZBTB16; SCEL; HDAC1; TXNRD1; KPNA2

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  44kDa

• References & Citations:

  Stoltzman, C.A., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (19), 6912-6917

• Shipping Conditions:

  Wet Ice

• Protein Length:

  391

• NCBI Gene Symbol:

  TXNIP

• NCBI GB Accession Number:

  TXNIP

• Host or Source:

  Rabbit

• Protein Name:

  Thioredoxin-interacting protein

• Nucleotide Accession Number:

  NM_006472

• Peptide Sequence:

  DTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPP