SIGIRR Antibody - C-terminal region : FITC (ARP49664_P050-FITC)

• Gene Name:

  Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

• Gene Aliases:

  TIR8, IL-1R8

• Gene ID:

  59307

• Swiss Prot:

  Q6IA17

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR

• Target:

  SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.

• Partner Proteins:

  APP; UBC; SIGIRR; TLR9; TLR5; TLR4; TRAF6; IRAK1; RPN1; IL1R1; ENO2

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  IHC, WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  25kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  224

• NCBI Gene Symbol:

  SIGIRR

• NCBI GB Accession Number:

  SIGIRR

• Host or Source:

  Rabbit

• Peptide Sequence:

  PVFGEPSAPPHTSGVSLGESRSSEVDVSDLGSRNYSARTDFYCLVSKDDM