COL18A1 Antibody - Middle region: HRP (ARP45877_P050-HRP)

• Gene Name:

  Collagen, type XVIII, alpha 1

• Gene Aliases:

  KS, KNO, GLCC, KNO1

• Gene ID:

  80781

• Swiss Prot:

  P39060-2

• Host:

  Rabbit

• Reactivity:

  Human, Cow, Horse, Pig, Rabbit

• Immunogen:

  The immunogen for Anti-COL18A1 antibody is: synthetic peptide directed towards the Middle region of Human COIA1

• Target:

  This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

• Partner Proteins:

  FUS; TUBG1; FBXO6; HNRNPD; TECPR1; GPC1; GPC4; KDR; FBLN2; ITGA5; MMP2; CTSL

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 92%; Horse: 83%; Human: 100%; Pig: 83%; Rabbit: 100%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  147 kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  1339

• NCBI Gene Symbol:

  COL18A1

• Protein Name:

  Collagen alpha-1 (XVIII) chain