DYRK1A Antibody - N-terminal region: FITC (ARP45797_P050-FITC)

• Gene Name:

  Dual-specificity tyrosine- (Y) -phosphorylation regulated kinase 1A

• Gene Aliases:

  MNB, DYRK, HP86, MNBH, MRD7, DYRK1

• Gene ID:

  1859

• Swiss Prot:

  Q13627

• Accession Number:

  NP_001387

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human DYRK1A

• Target:

  This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

• Partner Proteins:

  SUMO1; UBC; CCDC8; FAM117A; FAM53C; SIPA1L1; DCAF7; TROAP; KIAA0232; DYNLL1; RBL2; RBL1; RB1; ABCD3; PRKAR1A; FNTB; FNTA; EP300; DYRK1A; CREBBP; CCNA2; RNF169; FAM117B; DYNLL2; GLCCI1; PPP1R3F; LZTS2; PRKACB; PRKACA; TRAF3; BARD1; SNCA; MAP3K5; APP; SMAD3

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  85kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  763

• NCBI Gene Symbol:

  DYRK1A

• Protein Name:

  Dual specificity tyrosine-phosphorylation-regulated kinase 1A

• Nucleotide Accession Number:

  NM_001396