CALD1 Antibody - C-terminal region: Biotin (ARP42684_P050-Biotin)

• Gene Name:

  Caldesmon 1

• Gene Aliases:

  CDM, HCAD, LCAD, H-CAD, L-CAD, NAG22

• Gene ID:

  800

• Swiss Prot:

  Q05682

• Accession Number:

  NP_149129

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human CALD1

• Target:

  CALD1 is a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca (2+) -calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca (2+) -dependent inhibition of smooth muscle contraction.This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca (2+) -calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca (2+) -dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

• Partner Proteins:

  TP53; RPA3; RPA2; RPA1; PHAX; FH; EPB41L2; CSNK2A1; LRCH3; PRKACA; PAN2; UBC; HSP90AA1; CALM1; ACTN1; TINF2; POT1; ISG15; TERF1; ARRB1; Poc1b; Cep76; Sass6; Pafah1b1; TERF2; SHC1; CDK1; CALM3; GRB2

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  IHC, WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 86%; Dog: 86%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Yeast: 85%; Zebrafish: 86%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  93kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  793

• NCBI Gene Symbol:

  CALD1

• Protein Name:

  Caldesmon

• Nucleotide Accession Number:

  NM_033138