EZH2 Antibody - N-terminal region : FITC (ARP38470_P050-FITC)

• Gene Name:

  Enhancer of zeste homolog 2 (Drosophila)

• Gene Aliases:

  WVS, ENX1, KMT6, WVS2, ENX-1, EZH2b, KMT6A

• Gene ID:

  2146

• Swiss Prot:

  Q15910

• Accession Number:

  NP_004447.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human EZH2

• Target:

  EZH2 is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems.

• Partner Proteins:

  FBXW11; CEP63; HOTAIR; EED; BRCA1; SUZ12; SNAI1; SRSF1; SDCBP; UPF1; RBBP7; RBBP4; RAP1GAP; PLEC; PKM; POTEE; DHX36; AEBP2; HIST4H4; KLC4; SERPINB12; PHF5A; FIP1L1; FBXL18; CPSF7; DDX3X; DBN1; SLC25A10; COPB1; CALML3; ATP5C1; ATP5B; ATP2A2; ARG1; AR; ANXA

• Clonality:

  Polyclonal

• Conjugation:

  FITC: Fluorescein Isothiocyanate

• Type:

  Polyclonal Antibody

• Applications:

  IHC, WB

• Purification:

  Affinity Purified

• Sample Type:

  EZH2 is supported by BioGPS gene expression data to be expressed in MCF7

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  85kDa

• References & Citations:

  Mural, R.J., (2005) Direct Submission

• Shipping Conditions:

  Wet Ice

• Specificity:

  From peptide immunogen, will recognize all 5 isoforms.

• Protein Length:

  751

• NCBI Gene Symbol:

  EZH2

• NCBI GB Accession Number:

  EZH2

• Host or Source:

  Rabbit

• Protein Name:

  Histone-lysine N-methyltransferase EZH2

• Nucleotide Accession Number:

  NM_001203247

• Peptide Sequence:

  KGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQE