Runx1 Antibody - N-terminal region: Biotin (ARP37877_P050-Biotin)

• Gene Name:

  Runt related transcription factor 1

• Gene Aliases:

  AM, AML1, Cbfa, Pebp, Cbfa2, Pebp2a2, Pebpa2b, CBF-alpha-2

• Gene ID:

  12394

• Swiss Prot:

  Q03347-2

• Accession Number:

  NP_033951

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N-terminal region of MOUSE Runx1

• Target:

  CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Runx1 is essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Runx1 acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. It inhibits KAT6B-dependent transcriptional activation .

• Partner Proteins:

  Kat6a; Ubc; Cbfb; Foxp3; Rbbp4; Gata1; Fli1; Phc1; Cdk6; Cbx3; Bmi1; Pml; Mbd3; Smad2; Prmt1; Hdac2; Hcfc1; Gata2; Hdac1; Wdr5; Mta1; Smarcd1; Pcgf5; Smarcc2; Pold3; Smarce1; Set; Mta2; Ash2l; Tal1; Smarcc1; Smarcb1; Smarca4; Sin3a; Rnf2; Ring1; Cbfa2t3

• Clonality:

  Polyclonal

• Conjugation:

  Biotin

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 79%; Dog: 79%; Guinea Pig: 79%; Human: 79%; Mouse: 100%; Rabbit: 79%; Rat: 93%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  42kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  387

• NCBI Gene Symbol:

  RUNX1

• Protein Name:

  Runt-related transcription factor 1

• Nucleotide Accession Number:

  NM_009821