INTS6 Antibody - C-terminal region: HRP (ARP36404_P050-HRP)

• Gene Name:

  Integrator complex subunit 6

• Gene Aliases:

  HDB, INT6, DBI-1, DDX26, DICE1, DDX26A, Notchl2

• Gene ID:

  26512

• Swiss Prot:

  A8MV98

• Accession Number:

  NP_001035026

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human INTS6

• Target:

  DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. INTS6 is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH) . DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH) . Three transcript variants encoding two different isoforms have been found for this gene.

• Partner Proteins:

  RPA3; RPA2; RPA1; BMI1; UBC; MCM7; INTS10; CTDP1; SHFM1; DDX26B; NAIF1; INTS4; VWA9; INTS5; NABP2; C7orf26; INTS3; ZNF687; INTS2; INTS12; INTS9; ASUN; INTS8; CPSF3L; INTS6; INTS1; INTS7; ZMYND8; ZNF592; PPP2R1B; PPP2R1A; PPP2CB; PPP2CA; PPP1CB; POLR2L; PO

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity Purified

• Concentration:

  0.5 mg/mL

• Homology:

  Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  99kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  874

• NCBI Gene Symbol:

  INTS6

• Nucleotide Accession Number:

  NM_001039937