TP53 Antibody - C-terminal region: HRP (ARP30310_P050-HRP)

• Gene Name:

  Tumor protein p53

• Gene Aliases:

  P53, BCC7, LFS1, BMFS5, TRP53

• Gene ID:

  7157

• Swiss Prot:

  P04637

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Dog, Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C-terminal region of Human P53

• Target:

  This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277) .

• Clonality:

  Polyclonal

• Conjugation:

  HRP: Horseradish Peroxidase

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification:

  Affinity purified

• Concentration:

  0.5 mg/mL

• Homology:

  Dog: 90%; Human: 100%; Pig: 90%; Rabbit: 90%; Rat: 90%

• Format:

  Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

• Reconstitution:

  All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

• Molecular Weight:

  43kDa

• Shipping Conditions:

  Wet Ice

• Protein Length:

  393

• NCBI Gene Symbol:

  TP53

• Protein Name:

  Cellular tumor antigen p53