Anti-Hu CD371 PE-Cy™7

• Description:

  CD371, also known as CLEC12A, is a 30 kDa type II transmembrane glycoprotein of the C-type lectin family. Several alternatively spliced isoforms have been described. Using ITIM in its cytoplasmic part, this receptor serves as a negative regulator of CD371-positive cells, mainly granulocytes and monocytes, and is involved in dendritic cell maturation. It is one of markers of myeloid cells, including acute myeloid leukemia.

• Certification:

  RUO

• Immunogen:

  293T cells expressing human CD371-Flag

• Target Antigen:

  CD371

• Clone:

  50C1

• Applications:

  FC (QC tested)

• Format:

  PE-Cy™7

• Buffer:

  Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• References & Citations:

  *Lahoud MH, Proietto AI, Ahmet F, Kitsoulis S, Eidsmo L, Wu L, Sathe P, Pietersz S, Chang HW, Walker ID, Maraskovsky E, Braley H, Lew AM, Wright MD, Heath WR, Shortman K, Caminschi I: The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses. J Immunol. 2009 Jun 15;182 (12) :7587-94., URL: https://pubmed.ncbi.nlm.nih.gov/19494282/, *Coustan-Smith E, Song G, Shurtleff S, Yeoh AE, Chng WJ, Chen SP, Rubnitz JE, Pui CH, Downing JR, Campana D: Universal monitoring of minimal residual disease in acute myeloid leukemia. JCI Insight 2018 May 3;3 (9) :e98561. , URL: https://pubmed.ncbi.nlm.nih.gov/29720577/, *Shameli A, Dharmani-Khan P, Luider J, Auer I, Shabani-Rad MT: Exploring blast composition in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms: CD45RA and CD371 improve diagnostic value of flow cytometry through assessment of myeloblast heterogeneity and stem cell aberrancy. Cytometry B Clin Cytom. 2021 Sep;100 (5) :574-589., URL: https://pubmed.ncbi.nlm.nih.gov/33369070/

• Storage Conditions:

  Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

• Specificity:

  The mouse monoclonal antibody 50C1 recognizes an extracellular epitope of CD371, a type II transmembrane glycoprotein expressed above all on monocytes, macrophages, granulocytes and dendritic cells.

• Applications Notes:

  6

• Species:

  Human

• Isotype:

  Mouse IgG2a