Anti-Hu CD183 Purified

• Description:

  CD184 is a 7-transmembrane G-protein coupled receptor for the C-X-C chemokines SDF-1 (CXCL12), MIG (CXCL9) and IP10 (CXCL10) . Alternatively spliced variant CD184B serves as the high affinity receptor for PF4 (CXCL4) . CD184 is expressed in hematopoietic cells, vascular endothelium, and neural tissue. It plays important roles in endothelial vascularization and central nervous system development. It can also serve as a primary receptor or a coreceptor for some HIV isolates. CD184 signaling leads to integrin activation, cytoskeletal changes and chemotactic migration.

• Certification:

  RUO

• Target Antigen:

  CD183

• Clone:

  RHIQB005

• Applications:

  FC (QC tested)

• Concentration:

  1 mg/mL

• Format:

  Purified

• Buffer:

  Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• Storage Conditions:

  Store at 2-8°C. Do not freeze.

• Specificity:

  The recombinant mouse monoclonal antibody rHIQB005 recognizes an extracellular epitope on human chemokine receptor CD184.

• Applications Notes:

  Flow cytometry: Recommended dilution: 1-5 μg/ml

• Species:

  Human

• Isotype:

  Mouse IgG1