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Atpenin A5

CAT: 0804-HY-126653-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126653-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), and is an effective mKATP channel agonist and cardioprotective agent[1].
CAS Number
119509-24-9
UNSPSC
12352005
Hazard Statement
H301, H312, H330, H410
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/atpenin-a5.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C([C@@H](C)C[C@H](C)[C@@H](Cl)CCl)=O)=C(O)C(OC)=C(OC)N1
Molecular Formula
C15H21Cl2NO5
Molecular Weight
366.24
Precautions
H301, H312, H330, H410
References & Citations
[1]Andrew P Wojtovich, et al. The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels. Basic Res Cardiol. 2009 Mar;104 (2) :121-9.|[2]Jiyoung Bae, et al. Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration. Circulation. 2021 May 18;143 (20) :1973-1986.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
573317Atpenin A5
ALX-380-313-MC25Atpenin A5 (synthetic)
169935-01Atpenin A5 (3-[ (2S,4S,5R) -5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2 (1H) -pyridinone) discontinued
MBS651327-01Atpenin A5 (3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone)

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