NorA-IN-1

CAT: 0804-HY-156753-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-156753-01Size:5 mg

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Description

NorA-IN-1 (Compound 16) is a NorA inhibitor. NorA-IN-1 inhibits NorA efflux pump in everted membrane vesicles. NorA-IN-1 can be used for research of multidrug resistance[1].

CAS Number

1389310-69-3

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nora-in-1.html

Purity

96.55

Solubility

DMSO : 40 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl)

Smiles

O=C(C1=CC=C(C=C1)O)/C=C/C2=C(OC)C=C(OC)C=C2OC

Molecular Formula

C18H18O5

Molecular Weight

314.33

Precautions

H315, H319

References & Citations

[1]Holler JG, et al. Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles. Bioorg Med Chem. 2012 Jul 15;20 (14) :4514-21.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

2,4,6-Trimethoxy-4'-hydroxychalcone

CAS Number	1389310-69-3
PubChem CID	10495447
IUPAC Name	(E)-1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one
Molecular Formula	C18H18O5
Molecular Weight	314.3
XLogP	3.2
Topological Polar Surface Area	65
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Heavy Atom Count	23
Formal Charge	0
Complexity	386

SMILES

COC1=CC(=C(C(=C1)OC)/C=C/C(=O)C2=CC=C(C=C2)O)OC

InChI

InChI=1S/C18H18O5/c1-21-14-10-17(22-2)15(18(11-14)23-3)8-9-16(20)12-4-6-13(19)7-5-12/h4-11,19H,1-3H3/b9-8+

InChIKey

UJQJEKOZLIGAHH-CMDGGOBGSA-N

Chemical Structure

2D Structure

CAS: 1389310-69-3

CID: 10495447

Formula: C18H18O5

MW: 314.3

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	314.3
XLogP3	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	314.11542367
Monoisotopic Mass	314.11542367
Topological Polar Surface Area	65 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	386
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T81654-01	NorA-IN-1
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