Triamcinolone

• Description :

  Triamcinolone is a long-acting corticosteroid with anti-inflammatory, anti-oedematous, anti-proliferative, anti-angiogenetic, immunomodulatory and neuroprotective effects through binding to glucocorticoid receptors. Triamcinolone can relieve several dermatitis, immune diseases and ocular diseases[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H351

• Target :

  Glucocorticoid Receptor; Interleukin Related

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology; Endocrinology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Triamcinolone.html

• Concentration :

  10mM

• Purity :

  99.86

• Solubility :

  DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

• Smiles :

  F[C@@]1([C@]2(C=C3)C)[C@](CCC2=CC3=O)([H])[C@@](C[C@@H](O)[C@]4(O)C(CO)=O)([H])[C@]4(C)C[C@@H]1O

• Molecular Formula :

  C21H27FO6

• Molecular Weight :

  394.43

• Precautions :

  H351

• References & Citations :

  [1]McAlindon TE, et al. Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial. JAMA. 2017;317 (19) :1967-1975.|[2]Spandau UH, et al. Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo. Br J Ophthalmol. 2005 Jun;89 (6) :745-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [124-94-7]