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JKE-1674

CAT: 0804-HY-138153-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138153-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors[1][2][3].
CAS Number
2421119-60-8
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jke-1674.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : ≥ 50 mg/mL
Smiles
O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)/C(C[N+]([O-])=O)=N/O
Molecular Formula
C20H20Cl2N4O4
Molecular Weight
451.30
References & Citations
[1]Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020;16 (5) :497-506.|[2]Kathman SG, et al. A masked zinger to block GPX4. Nat Chem Biol. 2020;16 (5) :482-483.|[3]Viswanathan VS, et al. Unraveling Masked GPX4 Inhibitors. Nat. Chem. Biol. 2020, 16, 497–506.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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