Products for Research Use Only
RegisterLogin

(R) -Birabresib

CAT: 0804-HY-15743A-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15743A-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(R) -Birabresib is the isomer of Birabresib , and can be used as an experimental control. Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM.
CAS Number
1983196-25-3
Product Name Alternative
(R) -OTX-015; (R) -MK-8628
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Isomer
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-birabresib.html
Purity
99.94
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[C@@H]4CC(NC5=CC=C(O)C=C5)=O)C=C1
Molecular Formula
C25H22ClN5O2S
Molecular Weight
491.99
Precautions
H302, H315, H319, H335
References & Citations
[1]Marie-Magdelaine Coudé, et al. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget. 2015 Jul 10; 6 (19) : 17698–17712.|[2]Lu P, et al. The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb. Sci Rep. 2016 Apr 12;6:24100|[3]Vázquez R, et al. The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with RAD001. Oncotarget. 2017 Jan 31;8 (5) :7598-7613.|[4]J. Kay Noel, et al. Abstract C244: Development of the BET bromodomain inhibitor OTX015. Mol Cancer Ther November 2013 12; C244.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-15743-01Birabresib
HY-15743R-01Birabresib (Standard)
HY-W998245(R, R, R) -AHPC (hydrochloride)
HY-W018061C-01(R, R) -Traxoprodil
HY-103451(R, R) -THC
HY-113834(R, R) -Ethambutol
HY-128888-01(R, R) -GSK321
HY-100443B-01(R, R) -PX20606
HY-B0761(R, R) -Glycopyrrolate
HY-59125-01(R, R) - (+) -Hydrobenzoin

Alternative Products

CatalogName
BUP15366-01Birabresib
C17931Birabresib (OTX015)
A13890-500Birabresib (OTX015) 500mg
A13890-50Birabresib (OTX015) 50mg
A13890-2Birabresib (OTX015) 2mg
A13890-25Birabresib (OTX015) 25mg
A13890-10Birabresib (OTX015) 10mg
A13890-5Birabresib (OTX015) 5mg
A13890-200Birabresib (OTX015) 200mg
A13890-100Birabresib (OTX015) 100mg

Popular Products