Lafutidine (Standard)

• Description:

  Lafutidine (Standard) is the analytical standard of Lafutidine. This product is intended for research and analytical applications. Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease[1].

• Product Name Alternative:

  FRG-8813 (Standard)

• UNSPSC:

  12352005

• Target:

  Histamine Receptor; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

• Field of Research:

  Metabolic Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/lafutidine-standard.html

• Smiles:

  O=C (NC/C=C\COC1=NC=CC (CN2CCCCC2) =C1) CS (CC3=CC=CO3) =O

• Molecular Formula:

  C22H29N3O4S

• Molecular Weight:

  431.55

• References & Citations:

  [1]Motoko Nakano, et al. Possible involvement of host defense mechanism in the suppression of rat acute reflux esophagitis by the particular histamine H2 receptor antagonist lafutidine. Pharmacology. 2012;90 (3-4) :205-11.|[2]Tetsuhiro Sugiyama, et al. Lafutidine facilitates calcitonin gene-related peptide (CGRP) nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries. J Pharmacol Sci. 2008 Mar;106 (3) :505-11.|[3]Mitsuaki Okayama, et al. Protective effect of lafutidine, a novel histamine H2-receptor antagonist, on dextran sulfate sodium-induced colonic inflammation through capsaicin-sensitive afferent neurons in rats. Dig Dis Sci. 2004 Oct;49 (10) :1696-704.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  118288-08-7