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CYD19

CAT: 0804-HY-144315-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144315-03Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CYD19 is a potent Snail/HDAC dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis[1].
CAS Number
2415281-52-4
Product Name Alternative
Snail/HDAC-IN-1
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyd19.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(F)C=C1N)C2=CC=C(CSC(N=C3NC4=NNC(C)=C4)=NN5C3=CC=C5)C=C2
Molecular Formula
C24H21FN8OS
Molecular Weight
488.54
References & Citations
[1]Cui H, et al. Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumour cancer. Eur J Med Chem. 2022;229:114082.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1

Chemical Information

Snail/HDAC-IN-1
CAS Number2415281-52-4
PubChem CID153528580
IUPAC NameN-(2-amino-4-fluorophenyl)-4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylmethyl]benzamide
Molecular FormulaC24H21FN8OS
Molecular Weight488.5
XLogP3.9
Topological Polar Surface Area151
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count35
Formal Charge0
Complexity713
SMILES
CC1=CC(=NN1)NC2=NC(=NN3C2=CC=C3)SCC4=CC=C(C=C4)C(=O)NC5=C(C=C(C=C5)F)N
InChI
InChI=1S/C24H21FN8OS/c1-14-11-21(31-30-14)28-22-20-3-2-10-33(20)32-24(29-22)35-13-15-4-6-16(7-5-15)23(34)27-19-9-8-17(25)12-18(19)26/h2-12H,13,26H2,1H3,(H,27,34)(H2,28,29,30,31,32)
InChIKey
FWJQLBLNLGDLIU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Snail/HDAC-IN-1
CAS: 2415281-52-4
CID: 153528580
Formula: C24H21FN8OS
MW: 488.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight488.5
XLogP33.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass488.15430666
Monoisotopic Mass488.15430666
Topological Polar Surface Area151 Ų
Heavy Atom Count35
Formal Charge0
Complexity713
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A24076-10CYD19 (Snail/HDAC-IN-1) 10mg
A24076-5CYD19 (Snail/HDAC-IN-1) 5mg
A24076-100CYD19 (Snail/HDAC-IN-1) 100mg
A24076-50CYD19 (Snail/HDAC-IN-1) 50mg

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