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Lobeline (sulfate)

CAT: 0804-HY-128420-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128420-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation[1][2].
CAS Number
134-64-5
Product Name Alternative
α-Lobeline (sulfate) ; L-Lobeline (sulfate)
UNSPSC
12352005
Hazard Statement
H301
Target
Dopamine Transporter; nAChR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lobeline-sulfate.html
Solubility
10 mM in DMSO
Smiles
CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3.CN4[C@@H](CC(C5=CC=CC=C5)=O)CCC[C@H]4C[C@H](O)C6=CC=CC=C6.O=S(O)(O)=O
Molecular Formula
C44H56N2O8S
Molecular Weight
772.99
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Teng L, et al. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar;280 (3) :1432-44. |[2]https://mayoclinic.pure.elsevier.com/en/publications/a-smoking-cessation-trial-with-lobeline-sulfate-a-pilot-st|[3]Monzurul Amin Roni, et al. Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice. Alcohol. 2017 Jun:61:63-70.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
Launched

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