(+) -Usnic acid

CAT: 0804-HY-N0656A-01Size: 1 gDry Ice: NoHazardous: No
CAT#:0804-HY-N0656A-01Size:1 g
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Description
(+) -Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+) -Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer and anti-inflammatory activity. (+) -Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium[1][2][3].
CAS Number
[7562-61-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Bacterial; mTOR
Type
Natural Products
Related Pathways
Anti-infection; Autophagy; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/usnic-acid.html
Purity
99.63
Solubility
DMSO : ≥ 1.92 mg/mL|H2O : < 0.1 mg/mL
Smiles
O=C([C@@]1(C)C(OC2=C(C(C)=O)C(O)=C(C)C(O)=C12)=C3)C(C(C)=O)C3=O
Molecular Formula
C18H16O7
Molecular Weight
344.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Ebrahim HY, et al. Usnic Acid Benzylidene Analogues as Potent Mechanistic Target of Rapamycin Inhibitors for the Control of Breast Malignancies. J Nat Prod. 2017 Apr 28;80 (4) :932-952.|[2]Francolini I, et al. Usnic acid, a natural antimicrobial agent able to inhibit bacterial biofilm formation on polymer surfaces. Antimicrob Agents Chemother. 2004;48 (11) :4360-4365.|[3]Vijayakumar CS, et al. Anti-inflammatory activity of (+) -usnic acid. Fitoterapia. 2000 Sep;71 (5) :564-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MTORC1; mTORC2

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