Cholesterol-13C2

• Description:

  Cholesterol-13C2 is the 13C labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins[1][2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist[3].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite; Estrogen Receptor/ERR

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/cholesterol-13c2.html

• Purity:

  99.76

• Solubility:

  Ethanol : 5.56 mg/mL (ultrasonic)

• Smiles:

  C[C@@]12[C@] (CC[C@]2 ([H]) [C@H] (C) CCCC (C) C) ([H]) [C@@]3 ([H]) [C@@] (CC1) ([H]) [C@@]4 (C ([13CH2][13C@H] (CC4) O) =CC3) C

• Molecular Formula:

  C25 13C2H46O

• Molecular Weight:

  388.64

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  78887-48-6