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Abiraterone-d4

CAT: 0804-HY-70013S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-70013S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Abiraterone-d4 is the deuterium labeled Abiraterone. Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC50s of 2.5 nM and 15 nM, respectively.
CAS Number
2122245-62-7
Product Name Alternative
CB-7598-D4
UNSPSC
12352005
Target
Cytochrome P450
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
98.0
Solubility
Ethanol : 5 mg/mL (ultrasonic; warming)
Smiles
C[C@@]12C(C3=C([2H])N=C([2H])C([2H])=C3[2H])=CC[C@]1([C@@]4(CC=C5[C@@](C)([C@]4(CC2)[H])CC[C@@H](C5)O)[H])[H]
Molecular Formula
C24H27D4NO
Molecular Weight
353.53
References & Citations
[1]Attard G, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol. 2008 Oct 1;26 (28) :4563-71.; Richards J, et al. Interactions of|[2]Attard G, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol. 2008 Oct 1;26 (28) :4563-71.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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