Azosemide (Standard)

CAT: 0804-HY-107321R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107321R-01Size:5 mg
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Description
Azosemide (Standard) is the analytical standard of Azosemide. This product is intended for research and analytical applications. Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B, respectively[1].
CAS Number
[27589-33-9]
UNSPSC
12352100
Target
NKCC; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Metabolic Disease
Smiles
ClC1=CC(NCC2=CC=CS2)=C(C3=NN=NN3)C=C1S(N)(=O)=O
Molecular Formula
C12H11ClN6O2S2
Molecular Weight
370.84
References & Citations
[1]Hampel P, et al. Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B. Sci Rep. 2018 Jun 29;8 (1) :9877.|[2]Kim EJ, et al. Pharmacokinetics and pharmacodynamics of intravenous azosemide in mutant Nagaseanalbuminemic rats. Drug Metab Dispos. 2003 Feb;31 (2) :194-201.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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