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Dexetimide (hydrochloride)

CAT: 0804-HY-105545CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-105545CSize:1 Each
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Description
Dexetimide hydrochloride ((+) -Benzetimide hydrochloride) is an antimuscarinic drug with the activity of suppressing neuroleptic-induced Parkinson's syndrome. Dexetimide hydrochloride is used to improve the symptoms of movement disorders caused by the use of neuroleptics. Dexetimide hydrochloride, as the (-) -enantiomer of (-) -Benzetimide, shows the ability to selectively inhibit cholinergic receptors[1].
CAS Number
21888-96-0
Product Name Alternative
(+) -Benzetimide (hydrochloride) ; (S) - (+) -Dexetimide (hydrochloride) ; Dexbenzetimide (hydrochloride)
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dexetimide-hydrochloride.html
Smiles
O=C1[C@@](C2CCN(CC2)CC3=CC=CC=C3)(C4=CC=CC=C4)CCC(N1)=O.Cl
Molecular Formula
C23H27ClN2O2
Molecular Weight
398.93
References & Citations
[1]Speck AL, et al. The absolute configuration and crystal structure of the anticholinergic drug dexbenzetimide. Nature. 1971 Aug 20;232 (5312) :575-6.|[2]Müller-Gärtner HW, et al. Imaging muscarinic cholinergic receptors in human brain in vivo with Spect, [123I]4-iododexetimide, and [123I]4-iodolevetimide. J Cereb Blood Flow Metab. 1992 Jul;12 (4) :562-70.|[3]Dexetimide: an effective drug for the control of extrapyramidal symptoms induced by pipothiazine palmitate
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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