SHP2-IN-9
CAT:
804-HY-115925-02
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SHP2-IN-9
- CAS Number: 2987135-92-0
- UNSPSC Description: SHP2-IN-9 is a specific SHP2 inhibitor (IC50 =1.174 μM) with enhanced blood–brain barrier penetration. SHP2-IN-9 shows 85-fold more selective for SHP2 than SHP1. SHP2-IN-9 inhibits SHP2-mediated cell signal transduction and cancer cell proliferation, and inhibits the growth of cervix cancer tumors and glioblastoma growth in vivo[1].
- Target Antigen: Phosphatase; SHP2
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/shp2-in-9.html
- Purity: 98.68
- Solubility: DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(NCC1=CC=C(C=C1)F)CN2C=NC3=C(C4=C(S3)CCCCC4)C2=O
- Molecular Weight: 385.46
- References & Citations: [1]Ma Y, et al. Structure-based discovery of a specific SHP2 inhibitor with enhanced blood-brain barrier penetration from PubChem database. Bioorg Chem. 2022;121:105648.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported