Phorbol

• Description :

  Phorbol is the flagship member of the tigliane diterpene family. Phorbol can be isolated from natural sources and through semisynthesis. Phorbol can form esters that have a wide array of biological properties, which includes the induction of angiogenesis in vitro and promoting tumor in vivo[1][2][3].

• CAS Number :

  [17673-25-5]

• Product Name Alternative :

  4β-Phorbol

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319

• Target :

  Others

• Type :

  Natural Products

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Phorbol.html

• Purity :

  99.74

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 20 mg/mL

• Smiles :

  O=C1C(C)=C[C@@]2([H])[C@]3(O)[C@@]([C@@](C4(C)C)([H])[C@@]4(O)[C@H](O)[C@H]3C)([H])C=C(CO)C[C@]12O

• Molecular Formula :

  C20H28O6

• Molecular Weight :

  364.43

• Precautions :

  H315, H319

• References & Citations :

  [1]Kawamura, S., et al., (2016) . Nineteen-step total synthesis of (+) -phorbol. Nature, 532 (7597), 90–93. |[2]Montesano, R., & Orci, L. (1985) . Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell, 42 (2), 469–477.|[3]Blumberg P. M. (1980) . In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1. Critical reviews in toxicology, 8 (2), 153–197.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported