Products for Research Use Only
RegisterLogin

Lesinurad (sodium)

CAT: 0804-HY-15258A-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15258A-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.
CAS Number
1151516-14-1
Product Name Alternative
RDEA-594 sodium
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
OAT; URAT1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Lesinurad-sodium.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O[Na])CSC1=NN=C(Br)N1C2=C3C=CC=CC3=C(C4CC4)C=C2
Molecular Formula
C17H13BrN3NaO2S
Molecular Weight
426.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Shen Z, et al. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016 Jun;36 (6) :443-52|[2]Sattui SE, et al. Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications. Ther Adv Musculoskelet Dis. 2016 Aug;8 (4) :145-59.|[3]L.Yeh, et al. RDEA594, a potential uric acid lowering agent througn inhibition of uric acid reuptake , shows better pharmacokinetics rhan its prodrug RDEA806. 2008 ACR/ARHP Annual Scientific Meeting, 24-29 October 2008, USA.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched

Chemical Information

Lesinurad Sodium
CAS Number1151516-14-1
PubChem CID56928182
IUPAC Namesodium 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate
Molecular FormulaC17H13BrN3NaO2S
Molecular Weight426.3
Topological Polar Surface Area96.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity485
SMILES
C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)[O-].[Na+]
InChI
InChI=1S/C17H14BrN3O2S.Na/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14;/h1-4,7-8,10H,5-6,9H2,(H,22,23);/q;+1/p-1
InChIKey
FVYMVLTWIBGEMC-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of Lesinurad Sodium
CAS: 1151516-14-1
CID: 56928182
Formula: C17H13BrN3NaO2S
MW: 426.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight426.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass424.98095
Monoisotopic Mass424.98095
Topological Polar Surface Area96.1 Ų
Heavy Atom Count25
Formal Charge0
Complexity485
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-15258-01Lesinurad
HY-15258S1Lesinurad-d4
HY-N15194AInostamycin A (sodium)
HY-166084Docosatetraenoate (sodium)
HY-16366ABriciclib (sodium)
HY-150364AFarabursen (sodium)
HY-107943Tyropanoate (sodium)
HY-W009640AMofebutazone (sodium)
HY-22274-01DMPG (sodium)
HY-17474A-01Parecoxib (Sodium)

Alternative Products

CatalogName
OR1027806-01Lesinurad Sodium
A15973-200Lesinurad sodium 200mg
A15973-100Lesinurad sodium 100mg
A15973-50Lesinurad sodium 50mg
A15973-25Lesinurad sodium 25mg
A15973-10Lesinurad sodium 10mg
A15973-5Lesinurad sodium 5mg
A15973-2Lesinurad sodium 2mg
A15973-10mM-DLesinurad sodium 10mM * 1mL in DMSO
A3549-5Lesinurad

Popular Products