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Etifoxine (Standard)

CAT: 0804-HY-16579AR-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16579AR-01Size:5 mg
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Description
Etifoxine (Standard) is the analytical standard of Etifoxine. This product is intended for research and analytical applications. Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents[1][2][3].
CAS Number
21715-46-8
Product Name Alternative
HOE 36-801 (Standard)
UNSPSC
12352005
Target
GABA Receptor; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/etifoxine-standard.html
Smiles
ClC1=CC=C2C(C(C3=CC=CC=C3)(C)OC(NCC)=N2)=C1
Molecular Formula
C17H17ClN2O
Molecular Weight
300.78
References & Citations
[1]Marc Verleye, et al. Effects of etifoxine on ligand binding to GABA (A) receptors in rodents. Neurosci Res. 2002 Oct;44 (2) :167-72.|[2]Alain Hamon, et al. The modulatory effects of the anxiolytic etifoxine on GABA (A) receptors are mediated by the beta subunit. Neuropharmacology. 2003 Sep;45 (3) :293-303.|[3]Marc Verleye, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;21 (6) :457-70.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Etifoxine

Etifoxine is a benzoxazine.

CAS Number21715-46-8
PubChem CID135413553
IUPAC Name6-chloro-N-ethyl-4-methyl-4-phenyl-1H-3,1-benzoxazin-2-imine
Molecular FormulaC17H17ClN2O
Molecular Weight300.8
XLogP4.1
Topological Polar Surface Area33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity394
SMILES
CCN=C1NC2=C(C=C(C=C2)Cl)C(O1)(C)C3=CC=CC=C3
InChI
InChI=1S/C17H17ClN2O/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3,(H,19,20)
InChIKey
IBYCYJFUEJQSMK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Etifoxine
CAS: 21715-46-8
CID: 135413553
Formula: C17H17ClN2O
MW: 300.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight300.8
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass300.1029409
Monoisotopic Mass300.1029409
Topological Polar Surface Area33.6 Ų
Heavy Atom Count21
Formal Charge0
Complexity394
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS5754306Etifoxine
A3401-10Etifoxine hydrochloride
sc-218439Etifoxine-d3
AR-E02113-01Etifoxine Metabolite
526737Etifoxine HCl

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