Oncostatin-M (Human Recombinant)

• Description:

  Oncostatin-M (Human Recombinant)_x000D_ Catalog number: B2010320_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Volume/Weight: 10 ug_x000D_ pH: 7.4 upon reconstitution_x000D_ Supplied as: Lyophilized Powder_x000D_ Appearance: Powder_x000D_ Applications: highly pure Oncostatin-M (Human Recombinant) expressed in E. coli. This protein acts as a polypeptide chain containing 227 amino acids that acts as a cytokine belonging to the IL-6 family and has multiple functions in hematopoiesis and other functions._x000D_ Storage: -20C_x000D_ Keywords: rHuOSM; OSM_x000D_ Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Hermanns HM. Oncostatin M and interleukin-31: Cytokines, receptors, signal_x000D_ transduction and physiology. Cytokine Growth Factor Rev. 2015 Oct;26(5):545-58._x000D_ _x000D_ 2: West NR, Hegazy AN, Owens BMJ, Bullers SJ, Linggi B, Buonocore S, Coccia M,_x000D_ Görtz D, This S, Stockenhuber K, Pott J, Friedrich M, Ryzhakov G, Baribaud F,_x000D_ Brodmerkel C, Cieluch C, Rahman N, Müller-Newen G, Owens RJ, Kühl AA, Maloy KJ,_x000D_ Plevy SE; Oxford IBD Cohort Investigators, Keshav S, Travis SPL, Powrie F._x000D_ Oncostatin M drives intestinal inflammation and predicts response to tumor_x000D_ necrosis factor-neutralizing therapy in patients with inflammatory bowel_x000D_ disease. Nat Med. 2017 May;23(5):579-589._x000D_ _x000D_ 3: Verstockt S, Verstockt B, Vermeire S. Oncostatin M as a new diagnostic,_x000D_ prognostic and therapeutic target in inflammatory bowel disease (IBD). Expert_x000D_ Opin Ther Targets. 2019 Nov;23(11):943-954._x000D_ _x000D_ 4: Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y,_x000D_ Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW,_x000D_ Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K,_x000D_ Manabe I, Nagai R, Komuro I. Macrophage hypoxia signaling regulates cardiac_x000D_ fibrosis via Oncostatin M. Nat Commun. 2019 Jun 27;10(1):2824._x000D_ _x000D_ 5: Houben E, Hellings N, Broux B. Oncostatin M, an Underestimated Player in the_x000D_ Central Nervous System. Front Immunol. 2019 May 29;10:1165._x000D_ _x000D_ 6: Houben E, Janssens K, Hermans D, Vandooren J, Van den Haute C, Schepers M,_x000D_ Vanmierlo T, Lambrichts I, van Horssen J, Baekelandt V, Opdenakker G, Baron W,_x000D_ Broux B, Slaets H, Hellings N. Oncostatin M-induced astrocytic tissue inhibitor_x000D_ of metalloproteinases-1 drives remyelination. Proc Natl Acad Sci U S A. 2020 Mar_x000D_ 3;117(9):5028-5038._x000D_ _x000D_ 7: Matsuda M, Tsurusaki S, Miyata N, Saijou E, Okochi H, Miyajima A, Tanaka M._x000D_ Oncostatin M causes liver fibrosis by regulating cooperation between hepatic_x000D_ stellate cells and macrophages in mice. Hepatology. 2018 Jan;67(1):296-312._x000D_ _x000D_ 8: West NR, Owens BMJ, Hegazy AN. The oncostatin M-stromal cell axis in health_x000D_ and disease. Scand J Immunol. 2018 Sep;88(3):e12694._x000D_ _x000D_ 9: Stephens JM, Elks CM. Oncostatin M: Potential Implications for Malignancy and_x000D_ Metabolism. Curr Pharm Des. 2017;23(25):3645-3657._x000D_ _x000D_ 10: Wang ECE, Dai Z, Ferrante AW, Drake CG, Christiano AM. A Subset of_x000D_ TREM2⁺ Dermal Macrophages Secretes Oncostatin M to Maintain Hair_x000D_ Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell Stem Cell. 2019 Apr_x000D_ 4;24(4):654-669.e6._x000D_ 11: Foglia B, Sutti S, Pedicini D, Cannito S, Bocca C, Maggiora M, Bevacqua MR,_x000D_ Rosso C, Bugianesi E, Albano E, Novo E, Parola M. Oncostatin M, A Profibrogenic_x000D_ Mediator Overexpressed in Non-Alcoholic Fatty Liver Disease, Stimulates_x000D_ Migration of Hepatic Myofibroblasts. Cells. 2019 Dec 20;9(1):28._x000D_ _x000D_ Products Related to Oncostatin-M (Human Recombinant) : Proteins

• Short Description:

  Catalog Number: B2010320 (10 ug)_x000D_ Oncostatin-M (Human Recombinant) is a high quality research product used as highly pure Oncostatin-M (Human Recombinant) expressed in E. coli. This protein acts as a polypeptide chain containing 227 amino acids that acts as a cytokine belonging to the IL-6 family and has multiple functions in hematopoiesis and other functions. Custom bulk orders of this product are available upon request.

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3