Allocryptopine

• Description :

  Allocryptopine, a derivative of tetrahydropalmatine, is extracted from Macleaya cordata (Thunb.) Pers. Papaveraceae. Allocryptopine has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Potassium Channel

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/allocryptopine.html

• Concentration :

  10mM

• Purity :

  99.53

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1C(C(CCN(C)CC2=C(OC)C(OC)=CC=C2C1)=C3)=CC4=C3OCO4

• Molecular Formula :

  C21H23NO5

• Molecular Weight :

  369.41

• Precautions :

  H302

• References & Citations :

  [1]Xu B, et al. Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol. Evid Based Complement Alternat Med. 2015;2015:634172.|[2]Lin K, et al. Allocryptopine and benzyltetrahydropalmatine block hERG potassium channels expressed in HEK293 cells. Acta Pharmacol Sin. 2013 Jun;34 (6) :847-58.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [485-91-6]