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Gallocyanine (chloride)

CAT: 0804-HY-D0961-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D0961-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gallocyanine chloride is a synthetic blue dyestuff that can be used as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies. Gallocyanine chloride inhibits DKK1/LRP6 interaction (IC50=6.38 μM), activates Wnt signaling pathway, and causes β-catenin accumulation. Gallocyanine chloride exhibits anti-metastasis, anti-inflammatory and anti-fibrosis activities. Gallocyanine chloride can be used as a fluorescent probe for detection of superoxide anion radicals[1][2][3][4].
CAS Number
1562-85-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fluorescent Dye; Wnt; β-catenin
Type
Reference compound
Related Pathways
Others; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gallocyanine-chloride.html
Purity
92.00
Solubility
DMSO : 11.67 mg/mL (ultrasonic)
Smiles
OC1=C(O)C=C(C(O)=O)C2=C1[O+]=C3C=C(N(C)C)C=CC3=N2.[Cl-]
Molecular Formula
C15H13ClN2O5
Molecular Weight
336.73
Precautions
H302, H315, H319, H335
References & Citations
[1]Thysiadis S, et al., Design and synthesis of gallocyanine inhibitors of DKK1/LRP6 interactions for treatment of Alzheimer's disease. Bioorg Chem. 2018 Oct;80:230-244.|[2]Wu M, et al., Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis. Nat Commun. 2022 Mar 16;13 (1) :1371.|[3]Yang L, et al., Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. Cell Death Dis. 2020 Oct 4;11 (10) :827.|[4]Panasenko O M, et al. Gallocyanine as a Fluorogen for the Identification of NADPH-Dependent Production of Superoxide Anion Radical by Blood Cells[J]. Russian Journal of Bioorganic Chemistry, 2021, 47: 299-306.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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