Gallocyanine (chloride)

• Description:

  Gallocyanine chloride is a synthetic blue dyestuff that can be used as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies. Gallocyanine chloride inhibits DKK1/LRP6 interaction (IC50=6.38 μM), activates Wnt signaling pathway, and causes β-catenin accumulation. Gallocyanine chloride exhibits anti-metastasis, anti-inflammatory and anti-fibrosis activities. Gallocyanine chloride can be used as a fluorescent probe for detection of superoxide anion radicals[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Fluorescent Dye; Wnt; β-catenin

• Type:

  Reference compound

• Related Pathways:

  Others; Stem Cell/Wnt

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/gallocyanine-chloride.html

• Purity:

  92.00

• Solubility:

  DMSO : 11.67 mg/mL (ultrasonic)

• Smiles:

  OC1=C (O) C=C (C (O) =O) C2=C1[O+]=C3C=C (N (C) C) C=CC3=N2.[Cl-]

• Molecular Formula:

  C15H13ClN2O5

• Molecular Weight:

  336.73

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Thysiadis S, et al., Design and synthesis of gallocyanine inhibitors of DKK1/LRP6 interactions for treatment of Alzheimer's disease. Bioorg Chem. 2018 Oct;80:230-244.|[2]Wu M, et al., Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis. Nat Commun. 2022 Mar 16;13 (1) :1371.|[3]Yang L, et al., Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. Cell Death Dis. 2020 Oct 4;11 (10) :827.|[4]Panasenko O M, et al. Gallocyanine as a Fluorogen for the Identification of NADPH-Dependent Production of Superoxide Anion Radical by Blood Cells[J]. Russian Journal of Bioorganic Chemistry, 2021, 47: 299-306.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1562-85-2