GRN-529

• Description :

  GRN-529 is a negative allosteric modulator (NAM) for mGluR5. GRN-259 modulates sleep-wake activity, and exhibits anxiolytic efficacy in rats[1].

• CAS Number :

  [1253291-12-1]

• UNSPSC :

  12352005

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/grn-529.html

• Smiles :

  O=C(N1CC2=NC=CC=C2C1)C3=CC=C(C(C#CC4=NC=CC=C4)=C3)OC(F)F

• Molecular Formula :

  C22H15F2N3O2

• Molecular Weight :

  391.37

• References & Citations :

  [1]Harvey BD, et al., Neurophysiological signals as potential translatable biomarkers for modulation of metabotropic glutamate 5 receptors. Neuropharmacology. 2013 Dec;75:19-30.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported