10-Hydroxydecanoic acid

• UNSPSC Description:

  10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells[1][2][3][4][5].

• Target Antigen:

  Autophagy; Caspase; Interleukin Related; MDM-2/p53; NF-κB; NO Synthase; Parasite; RANKL/RANK ; TNF Receptor

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Apoptosis;Autophagy;Immunology/Inflammation;NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/NSC_15139.html

• Purity:

  98.77

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL

• Smiles:

  O=C(O)CCCCCCCCCO

• Molecular Weight:

  188.26

• References & Citations:

  [1]Takahashi K, et al. Inhibitory effect of 10-hydroxydecanoic acid on lipopolysaccharide-induced nitric oxide production via translational downregulation of interferon regulatory factor-1 in RAW264 murine macrophages. Biomed Res. 2013 Aug;34(4):205-14.|[2]Isayama, et al. "10-Hydroxydecanoic acid potentially elicits antigen-specific IgA responses." Biological and Pharmaceutical Bulletin 43.8 (2020): 1202-1209.|[3]Alkhaibari, et al. Insecticidal, antimalarial, and antileishmanial effects of royal jelly and its three main fatty acids, trans‐10‐hydroxy‐2‐decenoic acid, 10‐hydroxydecanoic acid, and sebacic acid. Evidence‐Based Complementary and Alternative Medicine 2022.1 (2022): 7425322.|[4]Mengmeng, et al. "10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells." International Immunopharmacology 84 (2020): 106501.|[5]Mengmeng, et al. "Combined royal jelly 10-hydroxydecanoic acid and aspirin has a synergistic effect against memory deficit and neuroinflammation." Food & Function 13.4 (2022): 2336-2353.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1679-53-4