(2S)-2'-Methoxykurarinone

(2S)-2'-Methoxykurarinone

• CAS Number: 270249-38-2
• UNSPSC Description: (2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells[1][2].
• Target Antigen: RANKL/RANK
• Type: Natural Products
• Related Pathways: NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/2s-2-methoxykurarinone.html
• Purity: 98.86
• Solubility: DMSO : 25 mg/mL (ultrasonic)
• Smiles: O=C1C[C@@H](C2=CC=C(O)C=C2OC)OC3=C(C[C@H](C(C)=C)C/C=C(C)\C)C(O)=CC(OC)=C13
• Molecular Weight: 452.54
• References & Citations: [1]Kim JY, et al. (2S)-2'-Methoxykurarinone inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. Biol Pharm Bull. 2014;37(2):255-61.|[2]Kang TH, et al. Cytotoxic lavandulyl flavanones from Sophora flavescens. J Nat Prod. 2000 May;63(5):680-1.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported