Recombinant Mouse/Rat TGF-beta 1

CAT:
855-EPT223
Size:
50 µg
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Recombinant Mouse/Rat TGF-beta 1 - image 1

Recombinant Mouse/Rat TGF-beta 1

  • Background:

    Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I) . Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
  • Description:

    Recombinant Mouse/Rat Transforming Growth Factor Beta 1 is produced by our Mammalian expression system and the target gene encoding Ala279-Ser390 is expressed.
  • Synonyms:

    TGF-beta-1; TGFB; TGF-b1; TGFB1; CEDLAP;latency-associated peptide; TGFbeta; TGF-beta 1 protein; transforming growth factor beta-1
  • UniProt:

    P04202
  • Accession Number:

    P04202
  • Endotoxin:

    Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
  • Purity:

    Greater than 95% as determined by reducing SDS-PAGE.
  • Bioactivity:

    Immobilized Mouse/Rat TGF-beta 1 (Cat#CK33) at 2μg/ml (100 μl/well) can bind Mouse TGFBR2-His (Cat#CM05) .The ED50 of Mouse TGFBR2-His (Cat#CM05) is 2.5 ug/ml.
  • Reconstitution:

    Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in 4mM HCl. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Molecular Weight:

    12.8 KDa
  • Shipping Conditions:

    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
  • Storage Conditions:

    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Notes:

    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Observed Molecular Weight:

    13 KDa, reducing conditions
  • Other Product Names:

    TGF-beta-1; TGFB; TGF-b1; TGFB1; CEDLAP; latency-associated peptide; TGFbeta; TGF-beta 1 protein; transforming growth factor beta-1
  • CAS Number:

    9000-83-3