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Recombinant Human CLEC10A (C-6His)

CAT: 0855-EPT070Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0855-EPT070Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc) . Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes.
Description
Recombinant Human C-Type Lectin Domain Family 10 Member A is produced by our Mammalian expression system and the target gene encoding Gln61-His316 is expressed with a 6His tag at the C-terminus.
UniProt
Q8IUN9
Accession Number
Q8IUN9
Endotoxin
Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Purity
Greater than 90% as determined by reducing SDS-PAGE.
Molecular Weight
29.8 KDa
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Storage Temperature
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Notes
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Observed Molecular Weight
40 KDa, reducing conditions
Other Product Names
C-Type Lectin Domain Family 10 Member A; C-Type Lectin Superfamily Member 14; Macrophage Lectin 2; CD301; CLEC10A; CLECSF13; CLECSF14; HML

UniProtKB · Q8IUN9

C-type lectin domain family 10 member A

CLC10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IUN9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLEC10A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K8J8, Q14538, Q6PIW3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityEndocytosisImmunityInnate immunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneEndosomeLysosomeMembrane

Domain

Coiled coilSignal-anchorTransmembraneTransmembrane helix

PTM

Disulfide bondGlycoprotein

Ligand

Lectin

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