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Recombinant Human Haptoglobin (C-6His)

CAT: 0855-EPT067Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0855-EPT067Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Haptoglobin (HP) is a secreted protein which is a member of the peptidase S1 family of serine proteases. As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
Description
Recombinant Human Haptoglobin/Zonulin is produced by our Mammalian expression system and the target gene encoding Val19-Gln160 (alpha chain) &Ile162-Asn406 (beta chain) is expressed with a 6His tag at the C-terminus.
UniProt
P00738
Accession Number
P00738
Endotoxin
Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Molecular Weight
15.9&28.3 KDa
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Storage Temperature
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Notes
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Observed Molecular Weight
16&40-75 KDa, reducing conditions
Other Product Names
Haptoglobin; Zonulin; HP

UniProtKB · P00738

Haptoglobin

HPT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P00738
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B0AZL5, P00737, Q0VAC4, Q0VAC5, Q2PP15, Q3B7J0, Q6LBY9, Q9UC67
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Acute phaseImmunity

Coding sequence diversity

Alternative splicing

Molecular function

AntibioticAntimicrobialAntioxidantSerine protease homolog

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Ligand

Hemoglobin-binding

Domain

RepeatSignalSushi

Cellular component

Secreted

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