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4-Methoxylonchocarpin

CAT: 0804-HY-N11768-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N11768-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS) -induced colitis mouse model[1].
CAS Number
51589-67-4
UNSPSC
12352005
Target
Interleukin Related; NF-κB; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-methoxylonchocarpin.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
OC1=C2C(OC(C)(C=C2)C)=CC=C1C(/C=C/C3=CC=C(C=C3)OC)=O
Molecular Formula
C21H20O4
Molecular Weight
336.38
References & Citations
[1]Jang HM, et al. 4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization. Int Immunopharmacol. 2017 Apr;45:90-97.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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