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Propargyl-PEG8-acid

CAT: 0804-HY-130379-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130379-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Propargyl-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . The ADCs can be used in bacterial infections caused by Gram-negative bacteria[1]. Propargyl-PEG8-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2055014-94-1
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; Bacterial; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/propargyl-peg8-acid.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
C#CCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O
Molecular Formula
C20H36O10
Molecular Weight
436.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; PEG Linkers

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