Recombinant Human Myocyte-specific enhancer factor 2C (MEF2C)

CAT: 0399-CSB-EP804958HUf2-01Size: 20 µgDry Ice: NoHazardous: No

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CAT#:0399-CSB-EP804958HUf2-01Size:20 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Product Name Alternative

Myocyte enhancer factor 2C

Abbreviation

Recombinant Human MEF2C protein

Gene Name

MEF2C

UniProt

Q06413

Expression Region

1-473aa

Organism

Homo sapiens (Human)

Target Sequence

MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT

Tag

C-terminal Flag-tagged

Type

Developed Protein

Source

E.coli

Field of Research

Cardiovascular

Relevance

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1.

Endotoxin

Not test

Purity

Greater than 85% as determined by SDS-PAGE.

Activity

Not Test

Form

Liquid or Lyophilized powder

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Molecular Weight

52.4 kDa

Storage Conditions

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Protein Length

Full Length

UniProtKB · Q06413

Myocyte-specific enhancer factor 2C

MEF2C_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q06413
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MEF2C
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: C9JMZ0, D7F7N5, F8W7V7

Protein keywords

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisDifferentiationNeurogenesisTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variantEpilepsyIntellectual disability

Technical term

Proteomics identificationReference proteome

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Alternative Products

Catalog	Name
485682	MEF2C (Myocyte-specific Enhancer Factor 2C, Myocyte Enhancer Factor 2C)
129559	MEF2C (Myocyte-specific Enhancer Factor 2C)
129559-HRP	MEF2C (Myocyte-specific Enhancer Factor 2C) (HRP)
M9769-97G	MEF2C (S59) (Myocyte-specific Enhancer Factor 2C)
129559-APC	MEF2C (Myocyte-specific Enhancer Factor 2C) (APC)
MBS6385246-01	MEF2C (Myocyte-specific Enhancer Factor 2C) (PE)
MBS6385238-01	MEF2C (Myocyte-specific Enhancer Factor 2C) (Biotin)
MBS6385237-01	MEF2C (Myocyte-specific Enhancer Factor 2C) APC
MBS6385236-01	MEF2C (Myocyte-specific Enhancer Factor 2C) (AP)
MBS631036-01	MEF2C (S387) (Myocyte-specific Enhancer Factor 2C)