Dienogest-13C,15N,d4

Dienogest-13C,15N,d4

• UNSPSC Description: Dienogest-13C,15N,d4 (STS 557-13C,15N,d4) is the 13C, 15N and deuterium labeled isotope of Dienogest (HY-B0084). Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE2 synthase and the activation of NF-κB. Dienogest can be used in studies of endometriosis, menopause and menorrhagia[1][2].
• Target Antigen: Isotope-Labeled Compounds; Progesterone Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: Others;Vitamin D Related/Nuclear Receptor
• Field of Research: Endocrinology
• Smiles: C[C@@]12[C@](O)(C([2H])([2H])[13C]#[15N])C([2H])([2H])C[C@@]1([H])[C@]3([H])CCC4=CC(CCC4=C3CC2)=O
• Molecular Weight: 317.43
• References & Citations: [1]Shimizu Y, et al. Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system. Steroids. 2011 Jan;76(1-2):60-7. |[2]Katayama H, et al. Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model. Hum Reprod. 2010 Nov;25(11):2851-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported