SARS-CoV-2-IN-81

SARS-CoV-2-IN-81

• UNSPSC Description: SARS-CoV-2-IN-81 (compound 12e) is a potent AAK1 inhibitor with an IC50 value of 9.38 nM. SARS-CoV-2-IN-81 shows anti-viral property against SARS-CoV-2. SARS-CoV-2-IN-81 attenuates AAK1-induced phosphorylation of AP2M1 threonine 156 and disrupts the direct interaction between AP2M1 and ACE2, ultimately inhibiting SARS-CoV-2 infection[1].
• Target Antigen: AAK1; SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection;Neuronal Signaling
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-in-81.html
• Solubility: 10 mM in DMSO
• Smiles: C12=CC(C3=CN=C(NC=C4C#CC5=CN=CC=C5)C4=C3)=CC=C1N(CCOC6)C6CO2
• Molecular Weight: 408.45
• References & Citations: [1]Nian-Dong Mao, et al. Design, synthesis and biological evaluation of novel 1,2,4a,5-tetrahydro-4H-benzo[b][1,4]oxazino[4,3-d][1,4]oxazine-based AAK1 inhibitors with anti-viral property against SARS-CoV-2. Eur J Med Chem. 2024 Feb 12:268:116232.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported