GSK2292767

CAT: 0804-HY-15280-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-15280-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GSK2292767 is a potent and selective inhibitor of PI3Kδ, with a pIC50 of 10.1. GSK2292767 showing greater than 500-fold selective over the other PI3K isoforms. GSK2292767 can be used for the research of respiratory disease[1].

CAS Number

1254036-66-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gsk2292767.html

Purity

98.89

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CS(=O)(NC1=CC(C2=CC3=C(C(C4=NC=C(CN5C[C@@H](C)O[C@@H](C)C5)O4)=C2)C=NN3)=CN=C1OC)=O

Molecular Formula

C24H28N6O5S

Molecular Weight

512.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Down K, et, al. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease. J Med Chem. 2015 Sep 24; 58 (18) : 7381-99.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

PI3Kδ

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GSK2292767

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