Lorlatinib

CAT: 1596-AR-L06197-02Size: 25 UnitsDry Ice: NoHazardous: No

1 / 1

CAT#:1596-AR-L06197-02Size:25 Units

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

1454846-35-5

Synonyms

(10R) -7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile

Molecular Formula

C21H19FN6O2

Molecular Weight

406.4

API Name

Lorlatinib

Chemical Information

Lorlatinib

Lorlatinib is a cyclic ether that is 16,17-dihydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one substituted by methyl groups at positions 2 and 10R, and by cyano, amino and fluoro groups at positions 3, 7 and 12 respectively. It is a small molecule inhibitor of ALK and ROS1 kinase developed by Pfizer for the treatment of ALK-positive non-small cell lung cancer. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a nitrile, a member of benzamides, a member of pyrazoles, an aromatic ether, a cyclic ether, an organic heterotetracyclic compound, an aminopyridine, an azamacrocycle and a member of monofluorobenzenes.

CAS Number	1454846-35-5
PubChem CID	71731823
IUPAC Name	(16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile
Molecular Formula	C21H19FN6O2
Molecular Weight	406.4
XLogP	1.5
Topological Polar Surface Area	110
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	0
Heavy Atom Count	30
Formal Charge	0
Complexity	700

SMILES

C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C

InChI

InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1

InChIKey

IIXWYSCJSQVBQM-LLVKDONJSA-N

Chemical Structure

2D Structure

CAS: 1454846-35-5

CID: 71731823

Formula: C21H19FN6O2

MW: 406.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	406.4
XLogP3	1.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	0
Exact Mass	406.15535203
Monoisotopic Mass	406.15535203
Topological Polar Surface Area	110 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	700
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
GTR19163173-01	Lorlatinib
HY-135509	Lorlatinib (acetate)
CS-O-59447	Lorlatinib-d6
ZBD20718	Lorlatinib acetate
HY-12215R-01	Lorlatinib (Standard)
C17977	Lorlatinib (PF-6463922)
CS-CX-00760	Lorlatinib 13C, d3
406533	Lorlatinib (PF-06463922)
GTR19281223-01	Lorlatinib impurity-1
RM-L151200-01	Lorlatinib (Pf 06463922)

Lorlatinib

Chemical Information

Alternative Products

Popular Products