Products for Research Use Only
RegisterLogin

Lorlatinib (Standard)

CAT: 0804-HY-12215R-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-12215R-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Lorlatinib (Standard) is the analytical standard of Lorlatinib. This product is intended for research and analytical applications. Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has Kis of L1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM (ALKL1196), 14-80 nM (ALKG1269A), 38-50 nM (ALK1151Tins), 77-113 nM (ALKG1202R), respectively[1][2][3].
CAS Number
1454846-35-5
Product Name Alternative
PF-06463922 (Standard)
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis; Reference Standards; ROS Kinase
Type
Reference Standards
Related Pathways
Apoptosis; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lorlatinib-standard.html
Purity
99.92
Smiles
CN1C(C#N)=C2C(CN(C)C(C3=C([C@@H](C)OC4=C(N)N=CC2=C4)C=C(F)C=C3)=O)=N1
Molecular Formula
C21H19FN6O2
Molecular Weight
406.41
References & Citations
[1]Johnson TW, et al. Discovery of (10R) -7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4- (metheno) pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations. J Med Chem. 2014 Jun 12;57 (11) :4720-44.|[2]Zou HY, et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking PF-02341066-resistant ROS1 mutations. Proc Natl Acad Sci U S A. 2015 Mar 17;112 (11) :3493-8|[3]Zou HY, et al. PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models. Cancer Cell. 2015 Jul 13;28 (1) :70-81.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

Related Products

CatalogName
HY-12215-01Lorlatinib
HY-135509Lorlatinib (acetate)
HY-P2274RArgifin (Standard)
HY-N9362REmodinanthrone (Standard)
HY-N7948RIsomaltotetraose (Standard)
HY-N7640RDeoxylimonin (Standard)
HY-N7617RToralactone (Standard)
HY-N7541RAntrodin A (Standard)
HY-N6739RBeauvericin (Standard)
HY-N6687RCalcimycin (Standard)

Alternative Products

CatalogName
GTR19163173-01Lorlatinib
AR-L06198-01Lorlatinib 13CD3
CS-O-59447Lorlatinib-d6
ZBD20718Lorlatinib acetate
S7536-10mM/1mLLorlatinib (PF-6463922)
CS-CX-00760Lorlatinib 13C, d3
406533Lorlatinib (PF-06463922)
GTR19281223-01Lorlatinib impurity-1
RM-L151200-01Lorlatinib (Pf 06463922)
A14207-100Lorlatinib (PF-06463922) 100mg

Popular Products