Cryogenine

CAT: 0804-HY-N8458-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-N8458-01Size:1 mg

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Description

Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50=424 μM) . Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.

CAS Number

10308-13-1

Product Name Alternative

NSC 272693

UNSPSC

12352005

Target

PGE synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cryogenine.html

Smiles

COC(C=C([C@@]1([H])N(CCCC2)[C@@]2([H])C[C@@](OC3=O)([H])C1)C(C(C=C(/C=C\3)C=C4)=C4O)=C5)=C5OC

Molecular Formula

C26H29NO5

Molecular Weight

435.51

References & Citations

[1]Lema, et al. Prostaglandin synthetase inhibition by alkaloids of Heimia salicifolia. J. Ethnopharmacol. 15 (2), 161-167 (1986) .

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

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T38327-01	Cryogenine

Cryogenine

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